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Cardiovascular response to hyperoxemia, hemodilution and burns [Elektronisk resurs] a clinical and experimental study

Bak, Zoltan, 1950- (författare)
Janerot Sjöberg, Birgitta (preses)
Hahn, Robert (opponent)
Linköpings universitet Institutionen för medicin och hälsa (utgivare)
Linköpings universitet Hälsouniversitetet (utgivare)
Publicerad: Institutionen för medicinsk teknik, 2007
Engelska.
Serie: Linköping University Medical Dissertations, 0345-0082 0345-0082 ; 1013
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  • E-bokAvhandling(Diss. (sammanfattning) Linköping : Linköpings universitet, 2007)
Sammanfattning Ämnesord
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  • The last decades less invasive monitoring and analytical tools have been developed for the evaluation of myocardial mechanics in clinical praxis. In critical care, these are longed-for complements to pulmonary artery catheter monitoring, additionally offering previously inaccessible information. This work is aimed, during fluid-replacement and oxygen therapy, to determine the physiological interface of ventricular and vascular mechanical properties, which result in the transfer of blood from the heart to appropriate circulatory beds. In prospective clinical studies we investigated previously cardiovascular healthy adults during hyperoxemia, and during preoperative acute normovolemic hemodilution or early fluid resuscitation of severe burn victims. Echocardiography was used in all studies, transthoracic for healthy volunteers and transesophageal for patients. For vascular parameters and for control purposes pulmonary artery Swan-Ganz catheter, calibrated external pulse recordings, whole body impedance cardiography, and transpulmonel thermodilution method were applied. We detected no significant change in blood pressure or heart rate, the two most often used parameters for patient monitoring. During preoperative acute normovolemic hemodilution a reduction of hemoglobin to 80 g/l did not compromise systolic or diastolic myocardial function. Cardiac volumes and flow increased with a concomitant fall in systemic vascular resistance while oxygen delivery seemed maintained. Supplemental oxygen therapy resulted in a linear dose-response between arterial oxygen and cardiovascular parameters, suggesting a direct vascular effect. Cardiac flow decreased and vascular resistance increased from hyperoxemia, and a decrease of venous return implied extracardial blood-pooling. Severe burns result in hypovolemic shock if not properly treated. The commonly used Parkland fluid replacement strategy, with urinary output and mean arterial pressure as endpoints, has recently been questioned. Applying this strategy, only transient early central hypovolemia was recorded, while dimensional preload, global left ventricular systolic function and oxygen delivery or consumption remained within normal ranges during the first 36 hours after accident. Signs of restrictive left ventricular diastolic function were detected in all patients and regional unstable systolic dysfunction was recognized in every other patient, and was consistent with myocardial marker leakage. Severe burns thereby cause myocardial stiffness and systolic regional dysfunction, which may not be prevented only by central normovolemia and adequate oxygenation. 

Ämnesord

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Anesthesiology and Intensive Care  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Anestesi och intensivvård  (hsv)
MEDICINE  (svep)
Surgery  (svep)
Anaesthetics and intensive care  (svep)
Intensive care  (svep)
MEDICIN  (svep)
Kirurgi  (svep)
Anestesiologi och intensivvård  (svep)
Intensivvård  (svep)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Anesthesia
general
Burns
Echocardiography
transesophageal
Hemodilution
emodynamic processes
Hyperoxia
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