Following the mevalonate pathway to bone heal alley / Björn Skoglund.

• The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. Using two different rodent models of fracture repair, a commonly used cholesterol lowering drug (statin) and two drugs used to treat osteoporosis (bisphosphonate) were applied both systemically as well as locally in order to enhance fracture repair. Papers I and II investigate the potential of simvastatin to improve the healing of femoral fractures in mice. Papers III and IV explore the use of two bisphosphonates to improve early fixation of stainless steel screws into rat bone. The statin simvastatin lead to an increased strength of the healing cellus. The application of bisphosphonates increased early screw fixation. It seems clear that both drugs have uses in orthopaedic applications. One interesting avenue of further research would be to combine the two classes of drugs and see if we can get the benefits while at the same time diminishing the drawbacks. 

Ämnesord

Bone screws  (MeSH)

Coated materials, biocompatible  -- chemistry (MeSH)

Diphosphonates  -- pharmacology (MeSH)

Equipment failure analysis  -- methods (MeSH)

Femoral fractures  -- drug therapy (MeSH)

Fracture fixation  -- instrumentation (MeSH)

Fracture fixation, internal  -- instrumentation (MeSH)

Fracture healing  -- drug effects (MeSH)

Simvastatin  -- pharmacology (MeSH)

Tibial fractures  -- physiopathology (MeSH)

Tibial fractures  -- surgery (MeSH)

Medical and Health Sciences  (ssif)

Basic Medicine  (ssif)

Medicinal Chemistry  (ssif)

Medicin och hälsovetenskap  (ssif)

Medicinska och farmaceutiska grundvetenskaper  (ssif)

Läkemedelskemi  (ssif)

Agricultural and Veterinary sciences  (ssif)

Veterinary Science  (ssif)

Other Veterinary Science  (ssif)

Lantbruksvetenskap och veterinärmedicin  (ssif)

Veterinärmedicin  (ssif)

Annan veterinärmedicin  (ssif)

PHARMACY  (svep)

Pharmaceutical chemistry  (svep)

FARMACI  (svep)

Farmaceutisk kemi  (svep)

VETERINARY MEDICINE  (svep)

Other veterinary medicine  (svep)

VETERINÄRMEDICIN  (svep)

Övrig veterinärmedicin  (svep)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Bone screws

coated materials

biocompatible

chemistry

diphosphonates

pharmacology

Equipment failure analysis methods

Femoral fractures

drug therapy

fracture fixation

instrumentation

Fracture fixation

fracture healing

drug effects

simvastatin

tibial fractures

physiopathologyial fractures

surgery

Vfo Ortopedi

Klassifikation

617.47 (DDC)

Vfo (kssb/8)