Shear stress in the common carotid artery is related to both intima-media thickness and echogenecity [Elektronisk resurs] the prospective investigation of the vasculature in Uppsala seniors study
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Lind, Lars (författare)
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Andersson, Jessika (författare)
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Larsson, Anders (författare)
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Sandhagen, Bo 1941- (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- 2009
- Engelska.
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Ingår i: Clinical hemorheology and microcirculation. - 1386-0291. ; 43:4, 299-308
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Sammanfattning
Ämnesord
Stäng
- It has previously been shown that the degree of shear stress (SS) in the carotid artery is related to both plaque occurrence and intima-media thickness (IMT). Since the echogenecity also is an important feature of plaques, we investigated if a reduced shear stress also is related to the echolucency of plaque and the intima-media complex. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population-based study of 1016 subjects aged 70, left common carotid artery diameter, IMT, the grey scale median (GSM) of the intima-media complex (IM-GSM) and the blood flow velocity were measured by ultrasound. Occurrence of plaque was noted, and the echogenecity of the plaques was visually estimated by the Gray-Weale classification. Shear stress was inversely related to both IMT and IM-GSM (p=0.0084 and p=0.003, respectively), independently of gender and coronary risk, estimated by the Framingham risk score. Shear stress was lower in subjects with carotid plaque (44% of the sample) than in those without (p=0.0013), and was inversely related to the echogenecity in the subjects with plaque (p=0.0092), independently of gender and coronary risk. A low shear stress in the common carotid artery was associated with both a thick IMT and an echolucent intima-media complex. A similar picture was seen when overt plaques were evaluated, suggesting that shear stress is of importance for both the extent and composition of atherosclerosis.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
- MEDICINE (svep)
- Dermatology and venerology,clinical genetics, internal medicine (svep)
- Internal medicine (svep)
- Cardiovascular medicine (svep)
- MEDICIN (svep)
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin (svep)
- Invärtesmedicin (svep)
- Kardiovaskulär medicin (svep)
Indexterm och SAB-rubrik
- Blood viscosity
- intima-media thickness
- plaques
- shear stress
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