Evolutionary tradeoffs and the geometry of gene expression space [Elektronisk resurs] / Uri Alon.
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Alon, Uri, 1969- (talare)
- London : Henry Stewart Talks, 2014.
- Engelska 1 online resource (1 streaming video file (36 min.)
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Serie: Systems biology, 2056-452X
- Relaterad länk:
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http://hstalks.com/l... (Table of Contents / Abstracts) (Series)
Innehållsförteckning
Ämnesord
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- Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems..
Ämnesord
- Bioinformatics. (LCSH)
- Biological models. (LCSH)
- Evolution (Biology). (LCSH)
- Gene expression. (LCSH)
- Mathematical optimization. (LCSH)
- Molecular biology. (LCSH)
- Morphology (Animals). (LCSH)
- Phenotype. (LCSH)
- Beak -- anatomy & histology. (MeSH)
- Biological Evolution. (MeSH)
- Computational biology. (MeSH)
- Evolution, Molecular. (MeSH)
- Fossils -- anatomy & histology. (MeSH)
- Gene Expression. (MeSH)
- Genes, Bacterial. (MeSH)
- Genetic Fitness. (MeSH)
- Models, Biological. (MeSH)
- Models, Statistical. (MeSH)
- Phenotype. (MeSH)
- Selection, Genetic. (MeSH)
- Systems Biology. (MeSH)
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