The hERG cardiac potassium channel [Elektronisk resurs] structure, function, and long QT syndrome.

• Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart / Gail A. Robertson, Eugenia M.C. Jones and Jinling Wang -- Structure-function studies of the outer mouth and voltage sensor domain of hERG / Gea-Ny Tseng and H. Robert Guy -- Voltage sensor movement in the hERG K channel / David R. Piper, Michael C. Sanguinetti and Martin Tristani-Firouzi -- hERG channel trafficking / Eckhard Ficker, Adrienne Dennis, Yuri Kuryshev, Barbara A. Wible and Arthur M. Brown -- Dynamic control of hERG/IKr by PKA-mediated interactions with 14-3-3 / Anna Kagan and Thomas V. McDonald -- Does hERG coassemble with a [beta] subunit? Evidence for roles of MinK and MiRP1 / Arun Anantharam and Geoffrey W. Abbott -- hERG block, QT liability and sudden cardiac death / Arthur M. Brown -- Structural determinants for high-affinity block of hERG potassium channels / John Mitcheson, Matthew Perry, Phillip Stansfeld, Michael C. Sanguinetti, Harry Witchel and Jules Hancox -- Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs / Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya, John Mitcheson and José A. Sanchez-Chapula -- In silico modelling : pharmacophores and hERG channel models / Maurizio Recanatini, Andrea Cavalli and Matteo Masetti -- The long QT syndrome : a clinical counterpart of hERG mutations / Peter J. Schwartz -- Cellular mechanisms of Torsade de Pointes / Steven Poelzing and David S. Rosenbaum -- Expression and role of hERG channels in cancer cells / Annarosa Arcangeli -- TRIad, foundation for proarrhythmia (triangulation, reverse use dependence and instability) / Luc M. Hondeghem -- Drug-induced QT interval prolongation : regulatory guidance and perspectives on hERG channel studies / Rashmi R Shah.

• This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.℗¡It features regulatory authority perspectives on preferred preclinical test systems and includes topics on℗¡hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. 

Ämnesord

Potassium channels  -- Congresses. (LCSH)

Long QT syndrome  -- Congresses. (LCSH)

Heart  -- Physiology -- Congresses. (LCSH)

Heart  -- Pathophysiology -- Congresses. (LCSH)

Potassium Channels, Voltage-Gated  -- chemistry -- Congresses. (MeSH)

Potassium Channels, Voltage-Gated  -- physiology -- Congresses. (MeSH)

Long QT Syndrome  -- physiopathology -- Congresses. (MeSH)

Arrhythmia  -- Congresses. (MeSH)

MEDICAL  -- Physiology. (bisacsh)

SCIENCE  -- Life Sciences -- Human Anatomy & Physiology. (bisacsh)

Genre

Electronic books. 

Indexterm och SAB-rubrik

Cardiac potassium channel

hERG

Klassifikation

QP114.M46 (LCC)

WG 330 (NLM)

MED (ämneskategori)

SCI (ämneskategori)

612.1/7 (DDC)

Veh (kssb/8 (machine generated))